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5 These guidelines align with the American Diabetes Association (ADA) standards of care which also provide strong recommendations based on robust clinical trial data supporting the cardiovascular benefits of GLP-1 RAs, particularly in patients with established cardiovascular disease and chronic kidney disease (CKD)

If unable to eat or drink, or experiencing persistent vomiting or diarrhoea, they should seek medical advice

The SUSTAIN clinical trial program evaluated semaglutide across multiple phase 3 trials involving over 8,000 participants with type 2 diabetes

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Rybelsus side effects The most common side effects of Rybelsus are: Nausea Stomach pain Diarrhea Poor appetite Vomiting Constipation Although rare, some people taking Rybelsus may experience serious side effects: Severe allergic reaction Kidney problems Gallbladder problems Low blood sugar (hypoglycemia) Pancreatitis (inflammation of the pancreas) Diabetic retinopathy in patients with Type 2 Diabetes Thyroid tumors, including medullary thyroid carcinoma, a rare but serious condition Warnings Rybelsus has a black box warning from the FDA for the risk of thyroid tumors or thyroid cancer