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The medication also carries warnings involving pancreatitis, diabetic retinopathy complications, acute kidney injury due to volume depletion, severe gastrointestinal adverse reactions, gallbladder disease, and other safety considerations

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By loading siNrf2 onto guanidino-terminated carboxysilane dendritic polymer (GCD) nanocarriers, Nrf2 gene expression can be specifically suppressed, significantly enhancing the sensitivity of cisplatin-resistant bladder cancer cells to cisplatin while maintaining a favorable safety profile (43)

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