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The influence of pharmaceutical companies, the need for clear clinical practice guidelines, and patient expectations further complicate the landscape
Vasodilation is achieved by activating endothelial nitric oxide synthase (eNOS) and increasing nitric oxide (NO) production via the cAMP/PKA, AMPK, and PI 3 K/Akt signaling pathways [17]
Many patients experience delays or denials, creating gaps in treatment
Nevertheless, the evidence points in the same direction as for Wegovy: Despite offering robust clinical benefits, in the short-term both products are not cost-saving due mainly to their high cost
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