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The tirzepatide group lost an additional 18.4% of their body weight over 72 weeks

It belongs to a class of medications known as dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonists

The peptide's mechanism of action involves three primary pathways: reduced appetite through central nervous system signaling, delayed gastric emptying that promotes satiety, and decreased food intake through enhanced fullness signals

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Real-world estimates suggest approximately 50% of GLP-1 users experience some form of localized reaction during their treatment course