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In the real-world settings, however, selection of antiobesity medications is not solely based on efficacy but also depends on other factors such as previous attempts to lose weight, comorbid medical conditions, coadministration of other medications, adverse effects from medications, insurance coverage, and patient preferences
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This is achieved through stimulation of pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons and the indirect inhibition of the orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) axis via GABAergic mechanisms.18 The partial permeability of the bloodbrain barrier in circumventricular structures and the arcuate nucleus, alongside potential GLP-1R-dependent involvement of tanycytes, facilitates the access of both LIRA and SEMA to brain regions that are essential in the regulation of food intake
J Pediatr 1982;101:782-5
Cell 167:843857
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