The expression of CSE is the most abundant in the liver, but low in the thyroid, pancreas, testis, ovary, and other endocrine glands (2426).3-MST is highly expressed in endocrine tissues (thyroid, parathyroid, adrenal), pancreas, gonad (testis, ovary) (27)
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The feedback inhibition of IGF-1 on further GH secretion stayed intact, preventing the GH excess that drives insulin resistance with direct injection