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That results in stable DNA adducts and can slow estrogen-sensitive cell growth and even reverse DNA damage caused by the 4-OHE1 pathway of Phase I metabolism
Many clinical observations suggest use 2-3 times per week rather than daily, with cycling periods to help maintain response over time
NPI-001 depleted cystine from human cystinosis fibroblast cells in culture statistically significantly greater than cysteamine
However, in a phase II evaluation of the compound in hepatocellular carcinoma, no objective response was shown (Wu et al., 2010)
Chapter 4 (Unit 4), 23
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