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A formal incretin analysis in humans was published in December of 1987 from Steven Blooms laboratory [32], clearly demonstrating the incretin-like insulinotropic potential of GLP-1, which was actually greater than that of GIP studied in the same experiments
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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)
Animal studies have shown potential developmental concerns with GLP-1 receptor agonists, though human pregnancy data remains sparse
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