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Results of the first phase 3 trial comparing orforglipron with oral semaglutide found that patients with diabetes lost on average 6-8% of their body weight with orforglipron, compared with 4-5% on semaglutide

The naturally occurring endocannabinoid anandamide also caused similar 24 h loss of cell viability in developing mouse cortical neurons at concentrations ranging from 1 to 100 mcg/mL, indicating the mechanism of cell death could be mediated through the cannabinoid receptors

There was a significant reduction in the risk of MACE of 3 points (RR 0.87

Over-the-Counter Remedies That May Help Simethicone (marketed as Gas-X) breaks up gas bubbles in the GI tract and reduces belching frequency

That's outdated thinking, he argues