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In contrast, overexpression of LEAP2 impairs the calorie restriction-induced increase in ghrelin levels in mice, suggesting that LEAP2 inhibits the biosynthesis or release of ghrelin (135)
Ancillary action has also been reported
GLP-1 agonists/analogues show beneficial effects on most of the multiple alterations underlying MASLD and cirrhosis progression [10]
This has not been confirmed in humans, but as a precaution, neither drug should be used by people with a personal or family history of medullary thyroid cancer (MTC) or a rare genetic condition called MEN2
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