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However, despite these broadly similar sets of findings, the mechanism for slowing of GLP-1R recycling with lixisenatide did not appear to depend on greater binding affinity, a factor that was previously demonstrated to influence the recycling of biased exendin-4-derived GLP-1R agonists (Jones et al., 2018b)

In the trial nausea and diarrhoea were the most common side effects, but they were typically mild to moderate, transient and subsided over time

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Brazil, Turkey, and other middle-income countries: Patents are expiring throughout 2026

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