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Mouse genotyping was performed with gene specific primers, summarized in Supplementary Table 1

The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

Additionally, this delivery method offers slow release over a 5-7 hour period

These results support FCHM as a promising therapeutic strategy against heavy metalinduced toxicity (7)

Moreover, the conversion of GGC to glutathione only requires 1 molecule of ATP as it is the product of the first step in glutathione synthesis, as shown in Figure 1