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It is important to seek medical advice before stopping and to create a long-term plan for weight management with your doctor

Evidence-based recommendations for type 2 diabetes management prioritise lifestyle interventions (diet, physical activity, weight management) alongside licensed pharmacological treatments such as metformin, SGLT2 inhibitors, or GLP-1 receptor agonists when indicated

GLP-1 receptor activation has been shown to counteract these mechanisms by reducing macrophage infiltration in adipose tissue, suppressing NF-Bmediated cytokine release, and promoting an anti-inflammatory immune profile (49)

Others lose 25% or more

Breast cancer staging: updates in the AJCC Cancer Staging Manual, 8th Edition, and current challenges for radiologists, from the AJR special series on cancer staging