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In patients with diabetes, GLP-1 RAs have been linked to an increased risk of age-related macular degeneration, although the overall risk is still low[38]

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GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPAR-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice

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