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however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
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When oxidative stress is excessive or prolonged, the free radicals produced can cause lipid peroxidation, protein denaturation, and nucleic acid base damage, and different biomarkers can reflect oxidative damage to various biomolecules
The agency had posted no final list addition for any of the seven peptides at the time of this update
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