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Additionally, there is an association between elevated glucose levels and the risk of thyroid cancer

The FDA shortage designation for semaglutide and tirzepatide - which originally provided the regulatory basis for much of the compounded GLP-1 market - has been resolved, and the FDA has proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list after stating it did not identify a clinical need for outsourcing facilities to compound those drugs from bulk substances

Helmstadter J, Frenis K, Filippou K, Grill A, Dib M, Kalinovic S, et al

In rare cases, they might cause mild digestive issues like upset stomach or diarrhoea