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The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience
Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
(Z)-Ligustilide is also able to reactivate ER, has epigenetic regulation, and is used in the study of tamoxifen -resistant breast cancer
Pettie et al., 2019
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