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A claim that an oral capsule produces systemic effects (fat loss, muscle repair, growth-hormone release, brain effects) should trigger immediate scrutiny, because systemic oral delivery of an unmodified peptide is precisely the hard problem that decades of formulation science have only partly solved for a handful of engineered drugs
This was done by examining the effects of BPC-157 on healing rodents that had intestinal anastomosis dehiscence
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Furthermore, myogenic progenitors derived from C9orf72 ALS patients displayed increased susceptibility to oxidative stress and dysregulation of mitochondrial genes, and these events were associated with mitochondrial abnormalities and toxicity (Lynch et al., 2019)
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