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While this can temporarily increase calorie burning, it often comes at a cost: anxiety, irritability, insomnia, digestive distress, and cardiovascular strain

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Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)

People who stopped the medication regained weight and saw metabolic markers return toward baseline, which suggests that GLP-1 therapy provides ongoing benefit rather than a one-time reset

It has been widely investigated in experimental research settings for its potential biological activity