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In our analysis, significant weight regain was observed only in the lower baseline BMI subgroups which did not conform to the common understanding, possibly because the enrolled patients were more severely obese and then not well differentiated by the BMI cutoff point, and the limited data in the analysis also reduced the confidence of the result
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At low doses, it temporarily blocks opioid receptors for a few hours, typically overnight, causing the brain to compensate by producing a surge of its own endogenous endorphins and enkephalins
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