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Improved Metabolic and Brain Health Obesity itself is associated with: Chronic inflammation Insulin resistance Hormonal dysregulation Increased depression and anxiety risk Improving metabolic health may indirectly improve mood and cognitive function in some patients

Nissen expects tirzepatide to soon join the pure GLP-1 RAs with an FDA-approved indication for weight loss in addition to diabetes, although it may meet the same payer reluctance around reimbursement for weight loss that the pure GLP-1 RAs have

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Ipamorelin is a selective third-generation GHRP that mimics ghrelin at the GHS-R1a receptor without significantly elevating cortisol or prolactin