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This allows NNMT inhibition to establish baseline NAD+ elevation, setting the metabolic stage for AMPK activation
One of the main identified targets is the nitric oxide (NO) pathway, where the peptide acts as a modulator of NO synthesis via NO synthase (NOS) enzymes
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The landmark Rudman study demonstrated that GH restoration in older men produced significant improvements in lean mass, fat mass, and skin thickness (9)
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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