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careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects

The reduction in sweet cravings is particularly valuable because sugar and processed carbohydrate consumption drives insulin-mediated hunger cycles that can perpetuate overeating independent of actual energy needs

& Michalopoulos, G