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Pharmacokinetic (PK) profiling in both species revealed linear doseexposure relationships, with [H] BPC157 rapidly metabolized into small peptides and ultimately tritium-labeled proline for normal amino acid catabolism/excretion [11]

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The resulting GSH or homoglutathione (-L-glutamyl-L-cysteinyl--alanine) conjugates were usually much less toxic and more water-soluble than the original xenobiotics (Brown and Neighbors, 1) (Bartling et al., 2002

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2011 Jan 25;4:105-13