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Gimbel, J
Betaine serves as an osmolyte and methyl group donor, playing a role in the re-methylation of homocysteine into methionine, a precursor of S-adenosylmethionine (SAM), essential for numerous methylation reactions, including DNA epigenetics ( De novo PC synthesis begins with the phosphorylation of choline by the enzyme choline kinase (ChoK) into phosphocholine ( Figure 2 )
occasional mild injection-site reactions (redness/itch) may occur with subcutaneous administration
Furthermore, the current UA elevation therapy shows unstable antioxidant properties, individual variability, and potential adverse effects, thus restricting its clinical applications [14]
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