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The resulting energy deficit manifests clinically as debilitating fatigue and post-exertional malaise (PEM), hallmark symptoms of both Long COVID and ME/CFS

Approximately 12% of patients may also experience renal failure in the setting of acute tubular necrosis with or without hepatic necrosis

1 Individual experiences with the Wegovy pen may vary

Looking back, what surprises me most is not where the science ended up, but how often progress began with unexpected observations made caring for patients

In other GLP-1 medications like Ozempic, Trulicity, or Victoza, fatigue is less frequently reported or not specifically listed as a common side effect in FDA prescribing information