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(Waldner 2006) A double-blind RCT (n=30) in patients receiving high-dose interleukin-2 therapy reported a reduction in serious cardiac events (e.g., arrhythmias and acute heart failure) with L-carnitine use compared to no therapy, but the small sample size and heterogeneity of the cancer types limit generalizability

Each added mechanism has lifted the ceiling, and the candidates now in development are built explicitly to climb it further