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Concentrated urine is more acidic, more irritating to the bladder lining, and creates a more favorable environment for bacterial colonization
and 150 mg kg 1 5FU (i.p.) alone or in combination with metformin
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However, this approach has also impacted Type 2 diabetes patients access to GLP-1s by requiring some patients to try other diabetes treatments (e.g., blood sugar regulators such as sodium-glucose cotransporter-2 inhibitor Brenzavvy and dipeptidyl peptidase-4 inhibitor Onglyza) before GLP-1 approval
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