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The inflammatory markers monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor (TNF- ), were reduced by treatment with exendin-4 in response to lipopolysaccharide in cultured peritoneal macrophages harvested from mice [65]
Her blood tests were unremarkable
butyricum cultured medium has been previously shown to significantly reduce TLR4 expression, an effect attributed to the metabolite butyrate
Reductions in proinflammatory cytokines such as IL-17, IL-23, and TNF- as detected by protein expression levels in immunohistochemistry, alongside histological improvements in epidermal thickness, support this anti-inflammatory mechanism
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