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The ADA and the European Association for the Study of Diabetes (EASD) recommend GLP-1 RAs (or SGLT2 inhibitors) with proven cardiovascular benefit for T2D patients with cardiovascular disease

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It regulates: Satiety signaling Insulin secretion Gastric emptying Postprandial glucose response Energy partitioning This is why the idea that the microbiome controls appetite is better understood as microbiome-influenced appetite signaling, where microbial metabolites may help shape satiety, gastric emptying, and metabolic response

2016 May 27;118(11):17031705