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Regarding Diabetes mellitus management, the effect of metformin, a classic anti-diabetic drug, on epilepsy is controversial: on the one hand, studies have confirmed that it, as an AMPK agonist, activates thalamic AMP-activated protein kinase, thereby enhancing metabotropic GABAB receptor function and ultimately promoting absence epileptic seizures (95)

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Trim37 ko1 and Trim37 cko embryos were incubated for 48 h at 4 C with anti-GFP (1:2000 dilution

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