Importantly, the observed LBM reduction has not consistently translated into functional impairment, and emerging evidence suggests that GLP-1 RAs may counterbalance this effect by improving muscle quality and metabolism [21]
FIGURE 1 Notably, the insulinotropic actions of circulating GLP-1 are facilitated through a two-domain binding interaction with GLP-1R (Figure 2), a structurally well-characterized prototypical class B GPCR, which recruits the G s -subunit of the heterotrimeric G-protein for cAMP-mediated downstream signaling, involving protein kinase A (PKA) and exchange protein activated by cAMP (EPAC), leading to insulin exocytosis
It mimics a natural hormone that regulates hunger, potentially reducing cravings and making it easier to adhere to healthier eating patterns
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