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Restoring mitochondrial biogenesis with metformin attenuates -GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

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A plateau at a given dose may represent your body is new set point at that medication level

Side Effects and Tolerability Profiles Both medications share common GLP-1 class side effects including nausea, vomiting, constipation, and mild diarrhea, particularly during dose escalation phases