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It regulates key angiogenic pathways by modulating the expression of vascular endothelial growth factor (VEGF), interleukins 6 and 8, hypoxia-inducible factor-1 alpha (HIF-1), and the activity of matrix metalloproteinases (MMPs)
Translating animal doses to human equivalents requires consideration of species-specific pharmacokinetic differences
This course may be administered twice annually, with at least a four month break in between courses
PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system
NJWA drafted figures
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