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To follow-up those studies and assess whether the results translated from rodents to primates, we conducted a 20-week study in obese, male cynomolgus monkeys testing GLP-1R agonism with both myostatin and activin A inhibition

The reduction in TKV in our study was associated with reductions in GFR and UACR, and, hence, a reduction in hyperfiltration could be a potential mechanism of the volume reduction

However, our average does not consider the border, the tumour grows through the border, in analogy with epithelial cell colony experiments where mitosis is localised at the border 16

NA, Not Applicable

These side effects are generally mild and often resolve with continued treatment