Avoid mechanical shear, avoid leaving concentrated solution standing at room temperature, and inspect for haze, filaments or opalescence before use
Homocysteine levels may also look normal on testing, cloaking genuine issues with methylation (a 'false negative')
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Prospective clinical trials are warranted to validate whether fluctuations in these blood-borne molecules can serve as early indicators of response to combination therapies involving ICIs and agents targeting RCD pathways (189, 190)
J Acquir Immune Defic Syndr Hum Retrovirol 19(5):498505 Alfirevic A, Stalford AC, Vilar FJ, Wilkins EG, Park BK, Pirmohamed M (2003) Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity