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In the presence of a transitional metal ion, lipid peroxide is catalyzed into OH (90), which have the ability to attract electrons from other PUFAs to generate new radicals and thereby propagating the lipid peroxidation chain reaction (91)

123 Besides, oxidative stress conditions also increase the innately high IDH1 expression, and IDH1 silencing significantly enhances cell sensitivity to cancer chemotherapy, radiotherapy, and photodynamic therapy by reducing NADPH

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Palazzuoli, V., Mondillo, S., Faglia, S., D'Aprile, N., Camporeale, A., and Gennari, C

Propofol and isoflurane enhancement of tonic gamma-aminobutyric acid type a current in cardiac vagal neurons in the nucleus ambiguus