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The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions

"Glutathione plays a large role in clearing estrogen metabolites from the body," she explains

Holy basil (Ocimum tenuiflorum) 125 mg of a standardized extract twice daily (Lopresti 2022) Supplementation associated with improvements in Perceived Stress Scale and Profile of Mood States, Athens Insomnia Scale scores

Furthermore, it can be costly, requiring multiple sessions to maintain its effects

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