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The CV incidence rate difference was larger among adults with pre-frailty or frailty

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Key points: People who received doses of retatrutide ranging from 1 mg (lowest dose) to 12 mg (highest dose) experienced significant weight loss compared to the placebo group At 24 weeks, the percentage change in body weight ranged from -7.2% in the 1 mg group to -17.5% in the 12 mg group, compared to -1.6% in the placebo group At 48 weeks, the percentage change in body weight ranged from -8.7% in the 1 mg group to -24.2% in the 12 mg group, compared to -2.1% in the placebo group A large proportion of people receiving retatrutide (64% to 100%) achieved an average weight loss of 5% or more, with some participants even losing 30% or more of their baseline weight Retatrutide treatment showed improvements in cholesterol levels, hypertension (high blood pressure) and blood glucose levels A recent paper published in The Lancet showed that combining retatrutide with lifestyle changes leads to significantly greater weight loss than lifestyle interventions without medication

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GLP-1 pathway GLP-1 receptor pathway research is commonly associated with appetite signalling, gastric emptying models and glucose-handling pathways