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The economic implications of obesity and diabetes are significant both in the real economy and in the revenue of large companies, with $1 out of every $4 in US health care costs is spent on caring for people with diabetes

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Fiber-rich diets add to these advantages by supplying fermentable substrates that boost SCFA generation, increase regulatory T-cell differentiation, modify microglial maturation, and improve BBB function

Additionally, metformin not only influences glucose metabolism in TC cells, but also suppresses mitochondrial respiration, which adds to its antitumor effect [267]