Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]
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Bicknell says an oral formulation of a protein is really exciting from a pharmacological perspective, as well as offering greater accessibility for patients
The most common adverse effects of GLP-1 receptor agonists are gastrointestinal, including nausea, vomiting, diarrhea, and constipation, which are typically dose-dependent
For people still on injectables, resources such as a stepbystep guide on injecting retatrutide can help make selfinjection feel more manageable