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continued using Bmal1 knockout mice and reported altered clock gene expression (Cry2 and Per2) along with decreased Nrd1, Dbp, Il1 , and Nox2 expression and increased Gsr and Lpl expression, indicating that Bmal1 regulates immune response and cellular metabolism in microglia (Wang et al., 2020)

Systemic reviews in 2025 still classify BPC157 as investigational, stressing that chronicuse safety in humans is unknown

Statistical analysis was conducted using SPSS version 14.0

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