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Wang B, Zhu S, Guo M, Ma R-D, Tang Y-L, Nie Y-X, et al

Mol Cancer 2015

While early-generation nanomedicines (such as liposomal mifamurtide) have historical clinical applications in osteosarcoma, and some nanocarriers like epirubicin micelles (NC-6300) have entered early-phase trials for general sarcomas, none of the advanced, multi-targeted nanomedicine-immunotherapy combination platforms discussed in this review have yet entered active clinical trials specifically for osteosarcoma

Do not inject through bruised, scarred, or irritated skin

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