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Impact on Claims GLP-1s now represent more than 10% of annual pharmacy claims for many employers in 2025a sharp rise compared to previous years (WorldatWork, IFEBP)
Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose
Supports lasting success Without adequate lifestyle changes and a focus on diet and exercise while taking GLP-1s, many people are at risk of regaining weight after they stop the medication
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