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By applying these inclusion and exclusion criteria, the review aimed to ensure the inclusion of relevant and high-quality studies that provide valuable insights into the role of oxidative stress, antioxidant interventions, and associated clinical trials in trisomy 21 or Down syndrome

Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]

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Common side effects include nausea, vomiting, and digestive discomfort, especially in the early days