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This fatty acid moiety enables reversible, non-covalent albumin binding in the systemic circulation, dramatically extending plasma half-life relative to both native amylin and earlier pramlintide analogues

These are rare at the doses used in supervised clinical care and when they occur, they're typically mild and transient

E., Orozco-Fuentes, S., Neganova, I., Lako, M., Shukurov, A., & Parker, N

Despite all the above-mentioned clinical benefits, the safety of long-term administration of this hormone remains controversial

Mulligan T, Frick MF, Zuraw QC, et al
