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We previously generated pancreas epitheliumspecific TGF- receptor type II (Tgfbr2) knockout mice in the context of Kras activation (mice referred to herein as Kras+Tgfbr2KO mice) and found that they developed aggressive PDAC that recapitulated the histological manifestations of the human disease
Studies probe pulsatile GH-axis modeling and dual-receptor pathway mapping
ROS includes free radicals like superoxide anion (O2) and hydroxyl radical (OH), while RNS includes nitric oxide (NO) and peroxynitrite (ONOO)
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