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GLP-1 medications or endoscopic procedures may serve as bridges to surgery

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Since igf-1r null animals and igf-1/igf-1r double knockouts have similar growth and skeletal defects, it is proposed that the IGF-1R mediates all activities induced by this growth factor ( IGF-1 FUNCTION IN OSTEOGENIC CELLS Because chondrocytes, osteoblasts, osteoclasts, and many other cells in the bone express IGF-1R and IGF-1, global igf-1 and igf-1r knockouts are unable to exclude the effect of systemic perturbations of IGF-1 signaling on the skeleton

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