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The free tripeptide chelates a single Cu(II) ion through its N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, giving the square-planar complex responsible for the deep blue colour of a reconstituted ghkcu solution

The decrease in intracellular antioxidants and subsequent rise in ROS levels interferes with glycolytic pathways, resulting in an energy crisis

Targeting early degenerative changes, such as synaptic loss, axonal transport disruption, mitochondrial compromise, and glial dysfunction, may prove more effective than attempting to reverse advanced neuronal death [27, 28]

Abstract Nutrient availability is a strong determinant of cell function

2015 Feb 6;12:7