Efficacy and Safety of Glucagon-Like Peptide-1/Glucagon Receptor Co-Agonist JNJ-64565111 in Individuals With Obesity Without Type 2 Diabetes Mellitus: A Randomized Dose-Ranging Study
Usage & Application Intended for professional use and administration Commonly used in skin whitening and anti-aging treatments Best results achieved with regular sessions and proper skincare Who Should Use It
Occurred in 8.8% of participants on 9 mg and 20.9% on 12 mg, compared to 0.7% on placebo Dose-dependent (higher dose, higher risk) Generally described as mild Rarely led to discontinuation Why this matters: Dysesthesia was not reported in the Phase 2 trial
Which Patients Are More Likely To Reach This Dose Level Not every patient progresses to the higher end of the titration range, and that is by design
Others opt for evening or night-time injections, particularly if they experience mild gastrointestinal side effects, though this approach is based on anecdotal experience rather than clinical evidence, especially for once-weekly formulations